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Jennifer Doudna, Nobel Prize-winning biochemist, discusses the present and future of CRISPR gene editing technologies, highlighting breakthrough therapies for sickle cell disease and rare genetic disorders, while exploring potential applications in agriculture, preventive medicine, and the intersection of CRISPR with AI.
Woosuk and Simon from UC Berkeley discuss their open-source inference engine VLLM and their new company Inferact, which aims to build a universal infrastructure layer for running AI models efficiently across different hardware and model architectures.
Nobel Prize-winning physicist Saul Perlmutter discusses the power of scientific thinking, collaboration, doubt, and the importance of critical thinking in navigating an increasingly complex and uncertain world.
Ken Goldberg explores the gap between AI language models and robotic manipulation, highlighting the complexity of tasks like tying shoelaces, and argues that while robotics has made progress in mobility and simple grasping, dexterous physical intelligence remains far more challenging than many expect.
A reflective compilation episode featuring powerful conversations from 2025 that explore themes of personal growth, longevity science, neuroplasticity, happiness, emotional regulation, consciousness, and the journey of transformation.
Alison Gopnik explores how children learn like scientists, challenging traditional views on nature versus nurture, consciousness, and intelligence by arguing that babies are more conscious and experimental than adults, and that AI should be viewed as a cultural technology rather than genuine intelligence.
Stuart Russell, a leading AI expert, warns that current AI development poses an existential risk to humanity, with top AI CEOs acknowledging a potentially 25% chance of extinction, and argues we need to fundamentally rethink how we develop AI to ensure it remains aligned with human interests.
Dr. Matthew Walker reveals groundbreaking sleep science, discussing the four pillars of sleep (quantity, quality, regularity, and timing), the importance of REM sleep, and how sleep impacts everything from genetic expression to mental health and creativity.
Tim Ferriss shares his personal journey of overcoming childhood sexual abuse and depression, revealing science-backed mental health tools like vagus nerve stimulation, accelerated TMS, metabolic psychiatry, and psychedelic therapy.
David Baszucki, co-founder of Roblox, discusses the platform's journey from a small startup to a global gaming and social platform with 120 million daily users, sharing insights on digital economies, AI innovation, creator empowerment, and his personal experiences with metabolic health and ketogenic therapy.
A groundbreaking interview with Nobel Prize in Physics winner John Martinis, who discusses his pioneering research on quantum mechanics, quantum computing, and how his early experimental work demonstrated quantum behavior at a macroscopic scale.
Ali Horowitz and Ben Ghodsi discuss the founding journey of Databricks, including navigating early challenges, making strategic pivots, building a high-performance culture, and turning down acquisition offers to pursue a bigger vision.
Sergey Levine discusses the rapid progress in robotics, predicting that fully autonomous robots capable of performing complex household tasks could be deployed within five years, driven by advances in AI, machine learning, and robotic foundation models.